ZTI-01 Treatment Improves Survival of Animals Infected with Multidrug Resistant Pseudomonas aeruginosa
نویسندگان
چکیده
1517. ZTI-01 Treatment Improves Survival of Animals Infected with Multidrug Resistant Pseudomonas aeruginosa Matthew B Lawrenz, PhD; Ashley Eb denDekker, BS, RLAT, LVT; Daniel E Cramer, PhD; Jon D Gabbard, PhD; Kathryn M Lafoe, BS, RALAT; Tia L Pfeffer, BA; Julie B Sotsky, PhD; Carol D Vanover, RLAT; Evelyn J. Ellis-Grosse, PhD and Jonathan M Warawa, PhD; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, Kentucky, Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville School of Medicine, Louisville, Kentucky, Zavante Therapeutics, Inc., San Diego, California
منابع مشابه
Delayed Therapy with Plasma Gelsolin Improves Survival in Murine Pneumococcal Pneumonia
1517. ZTI-01 Treatment Improves Survival of Animals Infected with Multidrug Resistant Pseudomonas aeruginosa Matthew B Lawrenz, PhD; Ashley Eb denDekker, BS, RLAT, LVT; Daniel E Cramer, PhD; Jon D Gabbard, PhD; Kathryn M Lafoe, BS, RALAT; Tia L Pfeffer, BA; Julie B Sotsky, PhD; Carol D Vanover, RLAT; Evelyn J. Ellis-Grosse, PhD and Jonathan M Warawa, PhD; Center for Predictive Medicine for Biod...
متن کاملEvaluation of the Efficacy of CD101, a Novel Echinocandin, in the Treatment of Candida auris Infection Using a Murine Model of Disseminated Candidiasis
1517. ZTI-01 Treatment Improves Survival of Animals Infected with Multidrug Resistant Pseudomonas aeruginosa Matthew B Lawrenz, PhD; Ashley Eb denDekker, BS, RLAT, LVT; Daniel E Cramer, PhD; Jon D Gabbard, PhD; Kathryn M Lafoe, BS, RALAT; Tia L Pfeffer, BA; Julie B Sotsky, PhD; Carol D Vanover, RLAT; Evelyn J. Ellis-Grosse, PhD and Jonathan M Warawa, PhD; Center for Predictive Medicine for Biod...
متن کاملIn Vivo Pharmacokinetics and Pharmacodynamics of ZTI-01 (Fosfomycin for Injection) in the Neutropenic Murine Thigh Infection Model against Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
Fosfomycin is a broad-spectrum agent with activity against Gram-positive and Gram-negative bacteria, including drug-resistant strains, such as extended-spectrum-beta-lactamase (ESBL)-producing and carbapenem-resistant (CR) Gram-negative rods. In the present study, the pharmacokinetic/pharmacodynamic (PK/PD) activity of ZTI-01 (fosfomycin for injection) was evaluated in the neutropenic murine th...
متن کاملMultidrug Resistance in Infants and Children
Bacterial infections may cause disease and death. Infants and children are often subject to bacterial infections. Antimicrobials kill bacteria protecting the infected patients andreducing the risk of morbidity and mortality caused by bacteria. The antibiotics may lose their antibacterial activity when they become resistant to a bacteria. The resistance to different antibiotics in a bacteria is ...
متن کاملLow concentrations of local honey modulate ETA expression, and quorum sensing related virulence in drug-resistant Pseudomonas aeruginosa recovered from infected burn wounds
Objective(s): Honey’s ability to kill microorganisms and even eradication of chronic infections with drug-resistant pathogens has been documented by numerous studies. The present study is focused on the action of honey in its sub-inhibitory levels to impact on the pathogens coordinated behaviors rather than killing them. Materials and Methods:</strong...
متن کامل